Boromycin Has Potent Anti- Toxoplasma and Anti- Cryptosporidium Activity-Reference-Cited by-同舟云学术

Boromycin Has Potent Anti- Toxoplasma and Anti- Cryptosporidium Activity

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abenoja Jaypee¹²,Cotto-Rosario Alexis¹,O’Connor Roberta¹^ORCID

Affiliation:

1. Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA

2. College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz, Nueva Ecija, Philippines

Abstract

Toxoplasma gondii and Cryptosporidium parvum , members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here, we describe the activity of the antibiotic boromycin against Toxoplasma and Cryptosporidium . Boromycin potently inhibited intracellular proliferation of both T. gondii and C. parvum at half-maximal effective concentrations (EC 50 ) of 2.27 nM and 4.99 nM, respectively.

Funder

HHS | NIH | National Center for Complementary and Integrative Health

Fulbright Association

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01278-20

Reference46 articles.

1. Toxoplasmosis

2. Toxoplasmic Encephalitis in AIDS