Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum-Reference-Cited by-同舟云学术

Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nava Maria G.¹,Calderón Félix²,Fernández Elena²,Ballell Lluis²,Bamborough Paul³,Vinayak Sumiti¹^ORCID

Affiliation:

1. Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

2. Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain

3. Molecular Design, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Abstract

The intestinal parasite Cryptosporidium parvum is a major cause of diarrhea-associated morbidity and mortality in children, immunocompromised people, and young ruminant animals. With no effective drug available to treat cryptosporidiosis in humans and animals, there is an urgent need to identify anti-parasitic compounds and new targets for drug development.

Funder

HHS | National Institutes of Health

UofI | University of Illinois at Urbana-Champaign

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03874-22

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