Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model-Reference-Cited by-同舟云学术

Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model

Published:1994-03 Issue:3 Volume:38 Page:616-619
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Condreay L D¹,Jansen R W¹,Powdrill T F¹,Johnson L C¹,Selleseth D W¹,Paff M T¹,Daluge S M¹,Painter G R¹,Furman P A¹,Ellis M N¹

Affiliation:

1. Division of Experimental Therapy, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709.

Abstract

A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when the mice were orally dosed with (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (FTC). No effects on tumor size or alpha-fetoprotein levels were observed. FTC can selectively inhibit HBV replication at nontoxic doses.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.3.616

Reference26 articles.

1. Efficient duck hepatitis B virus production by an avian liver tumor cell line;Condreay L. D.;J. Virol.,1990

2. Induction of drug metabolizing enzymes in human liver cell line Hep G2;Dawson J. R.;FEBS Lett.,1985

3. Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues;Doong S.;Proc. Natl. Acad. Sci. USA,1991

4. The influence of culture medium composition on drug metabolising enzyme activities of the human liver derived Hep G2 cell line;Doostdar H.;FEBS Lett.,1988

5. .Frick Lloyd. Personal communication.

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Selective Determination of Antiretroviral Agents Tenofovir, Emtricitabine, and Lamivudine in Human Plasma by a LC-MS-MS Method for a Bioequivalence Study in Healthy Indian Subjects;Journal of Chromatographic Science;2010-10-01

2. The Anti-Hepatitis B Virus Activity ofBoehmeria niveaExtract in HBV-Viremia SCID Mice;Evidence-Based Complementary and Alternative Medicine;2010

3. Synthesis and Antiviral Evaluation of Novel 2,3-Dihydroxypropyl Nucleosides from 2- and 4-Thiouracils;Nucleosides, Nucleotides and Nucleic Acids;2008-11-13

4. Synthesis of 2-Bromomethyl-3-Hydroxy-2-Hydroxymethyl-Propyl Pyrimidine and Theophylline Nucleosides Under Microwave Irradiation. Evaluation of Their Activity Against Hepatitis B Virus;Nucleosides, Nucleotides and Nucleic Acids;2006-09

5. The use of the hydrodynamic HBV animal model to study HBV biology and anti-viral therapy;Hepatology Research;2006-04