Author:
Arora Kriti,Ochoa-Montaño Bernardo,Tsang Patricia S.,Blundell Tom L.,Dawes Stephanie S.,Mizrahi Valerie,Bayliss Tracy,Mackenzie Claire J.,Cleghorn Laura A. T.,Ray Peter C.,Wyatt Paul G.,Uh Eugene,Lee Jinwoo,Barry Clifton E.,Boshoff Helena I.
Abstract
ABSTRACTWe report here a series of five chemically diverse scaffolds that havein vitroactivities on replicating and hypoxic nonreplicating bacilli by targeting the respiratorybc1complex inMycobacterium tuberculosisin a strain-dependent manner. Deletion of the cytochromebdoxidase generated a hypersusceptible mutant in which resistance was acquired by a mutation inqcrB. These results highlight the promiscuity of thebc1complex and the risk of targeting energy metabolism with new drugs.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
116 articles.
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