Resistance to Multiple Fluoroquinolones in a Clinical Isolate of Streptococcus pyogenes : Identification of gyrA and parC and Specification of Point Mutations Associated with Resistance-Reference-Cited by-同舟云学术

Resistance to Multiple Fluoroquinolones in a Clinical Isolate of Streptococcus pyogenes : Identification of gyrA and parC and Specification of Point Mutations Associated with Resistance

Published:2000-11 Issue:11 Volume:44 Page:3196-3198
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yan S. Steve¹,Fox Melissa L.²,Holland Steven M.²,Stock Frida¹,Gill Vee J.¹,Fedorko Daniel P.¹

Affiliation:

1. Microbiology Service, CPD, Clinical Center,1 and

2. the Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases,2 National Institutes of Health, Bethesda, Maryland 20892-1508

Abstract

ABSTRACT A strain of Streptococcus pyogenes resistant to multiple fluoroquinolones was isolated from the blood of an immunocompromised patient. Resistance to fluoroquinolones in S. pyogenes has not been previously studied. Compared to 10 sensitive strains of S. pyogenes , the fluoroquinolone-resistant clinical isolate of S. pyogenes presented point mutations in gyrA , predicting that serine-81 was changed to phenylalanine and that methionine-99 was changed to leucine, and in parC , predicting that serine-79 was changed to tyrosine. The mechanism of fluoroquinolone resistance in this isolate of S. pyogenes appears to be analogous to previously reported mechanisms for Streptococcus pneumoniae .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.11.3196-3198.2000

Reference18 articles.

1. Molecular Characterization of the Gene Encoding the DNA Gyrase A Subunit of Streptococcus pneumoniae

2. A review of the comparative in-vitro activities of 12 antimicrobial agents, with a focus on five new respiratory quinolones.;Blondeau J. M.;J. Antimicrob. Chemother.,1999

3. Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network.;Chen D. K.;N. Engl. J. Med.,1999

4. Mechanism of fluoroquinolone action.;Drlica K.;Curr. Opin. Microbiol.,1999

5. Ferraro M. J. Craig W. A. Dudley M. N. Eliopoulos G. Hecht D. W. Hindler J. Reller L. B. Sheldon A. T. Swenson J. M. Tenover F. C. Testa R. T. Weinstein M. P. Wikler M. A. NCCLS (ed.) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard 5th ed. M7-A5 and M100-S10 2000 NCCLS Wayne Pa

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