Complete Sequence of a KPC-Producing IncN Multidrug-Resistant Plasmid from an Epidemic Escherichia coli Sequence Type 131 Strain in China

Abstract

ABSTRACTWe report here the nucleotide sequence of a novelblaKPC-2-harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistantEscherichia colisequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genesblaKPC-2,blaCTX-M-3, andblaTEM-1; aminoglycoside acetyltransferase geneaac(6′)-Ib-cr; quinolone resistance geneqnrS1; rifampin resistance genearr-3; and trimethoprim resistance genedfrA14. The emergence of ablaKPC-2-harboring multidrug-resistant plasmid in an epidemicE. coliST131 clone poses a significant potential threat in community and hospital settings.