Aldose Reductase-Deficient Mice Develop Nephrogenic Diabetes Insipidus-Reference-Cited by-同舟云学术

Aldose Reductase-Deficient Mice Develop Nephrogenic Diabetes Insipidus

Published:2000-08-15 Issue:16 Volume:20 Page:5840-5846
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ho Horace T. B.¹,Chung Sookja K.¹,Law Janice W. S.¹,Ko Ben C. B.¹,Tam Sidney C. F.²,Brooks Heddwen L.³,Knepper Mark A.³,Chung Stephen S. M.¹

Affiliation:

1. Institute of Molecular Biology, The University of Hong Kong, 1 and

2. Division of Clinical Biochemistry, Queen Mary Hospital, 2 Hong Kong, China, and

3. Renal Mechanisms Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-16033

Abstract

ABSTRACT Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.20.16.5840-5846.2000

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