A siderophore production mutant of Bordetella bronchiseptica cannot use lactoferrin as an iron source

Author:

Foster L A1,Dyer D W1

Affiliation:

1. Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo 14214.

Abstract

Bordetella bronchiseptica secreted a hydroxamate siderophore when grown in Fe-depleted medium. A Tn5lac insertion mutant of B. bronchiseptica, DBB22, did not produce this hydroxamate siderophore and was incapable of using lactoferrin as an Fe source. Our data suggest that B. bronchiseptica uses a siderophore for removal of Fe from lactoferrin and transferrin rather than relying upon a receptor for these host Fe-binding proteins.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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2. Bordetella;Pathogenesis of Bacterial Infections in Animals;2010-05-12

3. Reduced Virulence of a Bordetella bronchiseptica Siderophore Mutant in Neonatal Swine;Infection and Immunity;2001-04

4. Lactoferrin;Natural Food Antimicrobial Systems;2000-06-21

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