The N-Terminal Region of the VP1 Protein of Swine Vesicular Disease Virus Contains a Neutralization Site That Arises upon Cell Attachment and Is Involved in Viral Entry-Reference-Cited by-同舟云学术

The N-Terminal Region of the VP1 Protein of Swine Vesicular Disease Virus Contains a Neutralization Site That Arises upon Cell Attachment and Is Involved in Viral Entry

Published:2001-01-15 Issue:2 Volume:75 Page:1044-1047
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jiménez-Clavero M. A.¹,Escribano-Romero E.¹,Douglas A. J.²,Ley V.¹

Affiliation:

1. Instituto Nacional de Investigación y Tecnologı́a Agraria y Alimentaria (INIA), 28040 Madrid, Spain,1 and

2. Department of Veterinary Science, Queens University, Belfast, Northern Ireland2

Abstract

ABSTRACT The N-terminal region of VP1 of swine vesicular disease virus (SVDV) is highly antigenic in swine, despite its internal location in the capsid. Here we show that antibodies to this region can block infection and that allowing the virus to attach to cells increases this blockage significantly. The results indicate that upon binding to the cell, SVDV capsid undergoes a conformational change that is temperature independent and that exposes the N terminus of VP1. This process makes this region accessible to antibodies which block virus entry.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.2.1044-1047.2001

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