Acute and Chronic Phases of Toxoplasma gondii Infection in Mice Modulate the Host Immune Responses-Reference-Cited by-同舟云学术

Acute and Chronic Phases of Toxoplasma gondii Infection in Mice Modulate the Host Immune Responses

Published:1998-06 Issue:6 Volume:66 Page:2991-2995
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Nguyen T. D.¹,Bigaignon G.¹,Van Broeck J.²,Vercammen M.³,Nguyen T. N.¹,Delmee M.¹,Turneer M.³,Wolf S. F.⁴,Coutelier J. P.²

Affiliation:

1. Microbiology Unit, Cliniques Universitaires Saint-Luc,1 and

2. Experimental Medicine Unit, ICP, Catholic University of Louvain,21200 Brussels, and

3. Institut Pasteur, 1180 Brussels,3 Belgium, and

4. Genetics Institute, Inc., Cambridge, Massachusetts 021404

Abstract

ABSTRACT Murine antibody responses to soluble proteins are generally restricted to the immunoglobulin G1 (IgG1) isotype. When mice were infected with Toxoplasma gondii Beverley and concomitantly immunized with a soluble unrelated protein antigen, a modification in the isotypic distribution of antibodies directed against this nonparasite antigen was observed, with a preferential production of IgG2a. Interestingly, when mice were immunized with a soluble protein antigen during the chronic phase (day 40) of infection with T. gondii Beverley, a similar modification in the isotypic distribution of antiprotein antibodies was observed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.6.2991-2995.1998

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