Genetic Differences between 129S Substrains Affect Antiretroviral Immune Responses

Author:

Zhang Robert Z.1,Mele Vincent1,Robben Lia1,Kane Melissa123ORCID

Affiliation:

1. Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. RK Mellon Institute for Pediatric Research, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA

3. Center for Microbial Pathogenesis, UPMC Children’s Hospital of Pittsburgh, Pittsburgh Pennsylvania, USA

Abstract

Understanding the genetic basis for production of protective antiviral immune responses is crucial for the development of novel vaccines and adjuvants. Additionally, characterizing the genetic and phenotypic variability in inbred mice has implications for the selection of strains for targeted mutagenesis, choice of controls, and for broader understanding of the requirements for protective immunity.

Funder

RK Mellon Institute for Pediatric Research

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference56 articles.

1. Rosenberg N, Jolicoeur P. 1997. Retroviral pathogenesis, p 475–586. In Coffin JM, Hughes SH, Varmus HE (ed), Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

2. Teich N, Wyke J, Bernstein A, Hardy W. 1982. Pathogenesis of retrovirus-induced disease, p 785–988. In Weiss R, Teich N, Varmus HE, Coffin JM (ed), RNA tumor viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

3. Characterization of a Novel Murine Retrovirus Mixture That Facilitates Hematopoiesis

4. Characterization of a preleukemic state induced by Moloney murine leukemia virus: evidence for two infection events during leukemogenesis.

5. Preleukemic hematopoietic hyperplasia induced by Moloney murine leukemia virus is an indirect consequence of viral infection

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