Physiological Regulation of the Derepressible Phosphate Transporter in Saccharomyces cerevisiae

Author:

Martinez Paula1,Zvyagilskaya Renata2,Allard Peter3,Persson Bengt L.14

Affiliation:

1. Department of Biochemistry, Arrhenius Laboratories for Natural Sciences, University of Stockholm, S-106 91 Stockholm,1

2. A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky Prospect 33, 117071, Moscow, Russia,2 and

3. Center for Structural Biochemistry, Novum, S-141 57 Huddinge,3 and

4. Department of Engineering and Natural Sciences, University of Växjö, S-351 95 Växjö,4 Sweden

Abstract

ABSTRACT The extracellular phosphate concentration permissive for the expression of different amounts of the active high-affinity Pho84 phosphate transporter in the plasma membrane as well as the PHO84 messenger RNA levels in low-phosphate-grown Saccharomyces cerevisiae cells is very narrow and essential for a tight regulation of the transporter. The Pho84 transporter undergoes a rapid degradation once the supply of phosphate and/or carbon source is exhausted.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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