Affiliation:
1. The State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan 250100, Shandong, China
Abstract
ABSTRACT
A
qnrVC
-like gene,
qnrVC4
, was found in a novel complex class 1 integron gene cassette array following the IS
CR1
element and
bla
PER-1
in a multidrug-resistant strain of the aquatic bacterium
Aeromonas punctata
. The deduced QnrVC4 protein sequence shares 45% to 81% amino acid identity with quinolone resistance determinants QnrB6, QnrA1, QnrS1, QnrC, QnrVC1, and QnrVC3. A Ser-83 to Ile amino acid substitution in gyrase A may be mainly responsible for ciprofloxacin resistance in this strain.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
77 articles.
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