Effects of Panton-Valentine Leukocidin of Staphylococcus aureus on Leukocytes from Patients with Leukemia

Author:

Blobel H.1,Wenk K.1,Kanoe M.1

Affiliation:

1. Institut für Bakteriologie und Immunologie Liebig-University, 63 Giessen, West Germany

Abstract

Mature granulocytes from six patients with myelocytic leukemia and monocytic cells from two patients with monocytic leukemia were damaged after incubation with leukocidin from Staphylococcus aureus . The immature granulocytes were not significantly affected. The lymphocytic cells from one patient with lymphocytic leukemia were not markedly damaged. The numbers of erythrocytes from all nine patients remained practically unchanged with lower concentrations of leukocidin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference6 articles.

1. Staphylococcal leucocidins;Gladstone G. P.;Brit. J. Exp. Pathol.,1957

2. Kanoe M. H. Blobel and W. Schaeg. 1969. Selektive Anreicherung von Staphylokokken-Panton-Valentine-Leukozidin mit Aluminiumoxid-Cholesterin. Z. Naturforsch. 24b:1431-1435.

3. Untersuchungen an "Leukozidinen;Wenk K.;von Staphylokokken verschiedener Herkunft. Zentralbl. Bakteriol. Parasitenk. Infektionskr. Abt. I,1970

4. Staphylococcal leucocidin;Woodin A. M.;Ann. N. Y. Acad. Sci.,1965

5. The cytotoxic effect of leucocidin;Woodin A. M.;Ciba Found. Symp. Cell. Inj.,1964

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1. Staphylococcus aureus Toxins: Armaments for a Significant Pathogen;Toxins;2019-08-03

2. Changes in binding of staphylococcal leukocidin to HL-60 cells during differentiation induced by dimethyl sulfoxide;Infection and Immunity;1988-09

3. Staphylococcal Leukocidin, Panton-Valentine Type;Journal of Toxicology: Toxin Reviews;1985-01

4. Antiphagocytic factors of Staphylococcus aureus;Comparative Immunology, Microbiology and Infectious Diseases;1980-01

5. A transient defect in leukocytic bactericidal capacity;Clinical Immunology and Immunopathology;1973-07

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