Identification of 16S rRNA Methylase-Producing Acinetobacter baumannii Clinical Strains in North America

Author:

Doi Yohei1,Adams Jennifer M.1,Yamane Kunikazu2,Paterson David L.134

Affiliation:

1. Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

2. Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan

3. University of Queensland, Brisbane, Australia

4. Queensland Health Pathology Services, Royal Brisbane and Women's Hospital, Brisbane, Australia

Abstract

ABSTRACT Five highly amikacin-resistant Acinetobacter baumannii isolates were collected at a medical center in Pennsylvania. The aminoglycoside resistance was due to the production of the 16S rRNA methylase ArmA. Two of the isolates coproduced OXA-23 β-lactamase and were highly resistant to carbapenems as well. The isolates were genetically closely related by pulsed-field gel electrophoresis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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