Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92-Reference-Cited by-同舟云学术

Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92

Published:2000-01 Issue:1 Volume:44 Page:196-199
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Donald Helen M.¹,Scaife Wendy¹,Amyes Sebastian G. B.²,Young Hilary-Kay¹

Affiliation:

1. Department of Biological Sciences, University of Dundee, Dundee DD1 4HN,1 and

2. Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG,2 United Kingdom

Abstract

ABSTRACT The sequence of the bla ARI-1 gene from imipenem-resistant Acinetobacter baumannii 6B92 has been determined. The structural gene encodes a 273-amino-acid protein which is most related to the OXA class D β-lactamases. The conserved S-T-F-K and K-T-G motifs were identified in the ARI-1 protein sequence, also named OXA-23, but significantly, a point mutation (Y→F) was identified in the Y-G-N conserved motif, also known to function in the active site.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.1.196-199.2000

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