A Variant Allele in Varicella-Zoster Virus Glycoprotein B Selected during Production of the Varicella Vaccine Contributes to Its Attenuation-Reference-Cited by-同舟云学术

A Variant Allele in Varicella-Zoster Virus Glycoprotein B Selected during Production of the Varicella Vaccine Contributes to Its Attenuation

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sadaoka Tomohiko¹²^ORCID,Depledge Daniel P.³⁴⁵^ORCID,Rajbhandari Labchan⁶,Breuer Judith⁷,Venkatesan Arun⁶^ORCID,Cohen Jeffrey I.²

Affiliation:

1. Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

2. Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

3. Department of Microbiology, New York University School of Medicine, New York, USA

4. Institute for Virology, Hannover Medical School, Hannover, Germany

5. German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany

6. Division of Neuroimmunology and Neuroinfectious Diseases, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

7. MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom

Abstract

The live-attenuated varicella vaccine has reduced the burden of chickenpox. Despite its development in 1974, the molecular basis for its attenuation is still not well understood.

Funder

MEXT | Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

The Tokyo Biomedical Research Foundation

Japan Herpesvirus Infections Forum

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

UCL/UCLH Biomedical Research Centre

The Maryland Stem Cell Research Fund

NIH NINDS

Publisher

American Society for Microbiology

Subject