Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium-Reference-Cited by-同舟云学术

Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium

Published:1990-02 Issue:2 Volume:172 Page:1137-1141
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Zhu Y F¹,Curran I H¹,Joris B¹,Ghuysen J M¹,Lampen J O¹

Affiliation:

1. Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855-0759.

Abstract

The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A beta-lactamase. The protein product, BlaR, has a hydrophilic carboxy region that binds beta-lactams and shows high sequence homology to the class D beta-lactamases, particularly the OXA-2 beta-lactamase of Salmonella typhimurium. The BlaR-beta-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.172.2.1137-1141.1990

Reference19 articles.

1. The structure of P-lactamases;Ambler R. P.;Philos. Trans. R. Soc. London B,1980

2. Sequence of the Oxa-2 1-lactamase: comparison with other penicillin-reactive enzymes;Dale J. W.;FEBS Lett.,1985

3. Nucleotide sequence of the gene encoding the Streptomyces albus G ,-lactamase precursor;Dehotty P.;Eur. J. Biochem.,1987

4. The crystal structure of the ,-lactamase of Streptomyces albus G at 0.3 nm resolution;Dideberg O.;Biochem. J.,1987

5. The genetics of Bacillus licheniformis penicillinase: a preliminary analysis from studies on mutation and inter-strain and intra-strain transformations;Dubnau D. A.;J. Gen. Microbiol.,1965

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