In Vivo Activity of a Novel Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin, Ceftaroline, against Vancomycin-Susceptible and -Resistant Enterococcus faecalis Strains in a Rabbit Endocarditis Model: a Comparative Study with Linezolid and Vancomycin-Reference-Cited by-同舟云学术

In Vivo Activity of a Novel Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin, Ceftaroline, against Vancomycin-Susceptible and -Resistant Enterococcus faecalis Strains in a Rabbit Endocarditis Model: a Comparative Study with Linezolid and Vancomycin

Published:2009-12 Issue:12 Volume:53 Page:5300-5302
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jacqueline Cédric¹,Caillon Jocelyne¹,Le Mabecque Virginie¹,Miègeville Anne-Françoise¹,Ge Yigong²,Biek Donald²,Batard Eric¹,Potel Gilles¹

Affiliation:

1. Université de Nantes, Nantes Atlantique Universités, Thérapeutiques Cliniques et Expérimentales des Infections, EA3826, UFR Médecine, Nantes, France

2. Cerexa, Inc., Oakland, California

Abstract

ABSTRACT We assessed the in vitro and in vivo efficacy of the novel parenteral broad-spectrum cephalosporin ceftaroline against Enterococcus faecalis in time-kill experiments and in a rabbit endocarditis model with simulated human dosing. Ceftaroline was more active than either vancomycin or linezolid against vancomycin-sensitive and -resistant isolates of E . faecalis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00984-09

Reference17 articles.

1. Amsterdam, D. 1996. Susceptibility testing of antibiotics in liquid media, p. 52-111. In V. Lorian (ed.), Antibiotics in laboratory medicine, 4th ed. The Williams & Wilkins Co., Baltimore, MD.

2. Bugnon, D., G. Potel, J. Caillon, D. Baron, H. B. Drugeon, P. Feigel, and M. F. Kergueris. 1998. In vivo simulation of human pharmacokinetics in the rabbit. Bull. Math. Biol.60:545-567.

3. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 2006

4. Durack, D. T., and P. B. Beeson. 1972. Experimental bacterial endocarditis. II. Survival of bacteria in endocardial vegetations. Br. J. Exp. Pathol.53:50-53.

5. Teicoplanin versus vancomycin for prophylaxis of experimental Enterococcus faecalis endocarditis in rats

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enteroccocus and Endocarditis;Infectious Diseases;2024-06-11

2. New Antimicrobials and New Therapy Strategies for Endocarditis: Weapons That Should Be Defended;Journal of Clinical Medicine;2023-12-14

3. Treatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge;Antibiotics;2023-04-04

4. Dose Optimization of Combined Linezolid and Fosfomycin against Enterococcus by Using an In Vitro Pharmacokinetic/Pharmacodynamic Model;Microbiology Spectrum;2021-12-22

5. Pharmacodynamics of Linezolid Plus Fosfomycin Against Vancomycin–Resistant Enterococcus faecium in a Hollow Fiber Infection Model;Frontiers in Microbiology;2021-12-14