Dose Optimization of Combined Linezolid and Fosfomycin against Enterococcus by Using an In Vitro Pharmacokinetic/Pharmacodynamic Model

Author:

Mao Jun12,Li Ting3,Zhang Na12,Wang Shuaishuai12,Li Yaowen12,Peng Yu12,Liu Huiping12,Yang Guang12,Yan Yisong12,Jiang Lifang12,Liu Yanyan4,Li Jiabin4,Huang Xiaohui12ORCID

Affiliation:

1. Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, China

2. Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, China

3. Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China

4. Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China

Abstract

In this study, we found that linezolid combined with fosfomycin could kill Enterococcus in vitro and that the administered dose was significantly lower after the combination treatment, which could reduce adverse effects and the development of drug resistance. The potential mechanism of the two-drug combination against Enterococcus was revealed from a quantitative perspective, which is an important step toward dose optimization in simulated humans.

Funder

Anhui Medical University

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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