Dose Optimization of Combined Linezolid and Fosfomycin against Enterococcus by Using an In Vitro Pharmacokinetic/Pharmacodynamic Model-Reference-Cited by-同舟云学术

Dose Optimization of Combined Linezolid and Fosfomycin against Enterococcus by Using an In Vitro Pharmacokinetic/Pharmacodynamic Model

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Mao Jun¹²,Li Ting³,Zhang Na¹²,Wang Shuaishuai¹²,Li Yaowen¹²,Peng Yu¹²,Liu Huiping¹²,Yang Guang¹²,Yan Yisong¹²,Jiang Lifang¹²,Liu Yanyan⁴,Li Jiabin⁴,Huang Xiaohui¹²^ORCID

Affiliation:

1. Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, China

2. Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, China

3. Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China

4. Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China

Abstract

In this study, we found that linezolid combined with fosfomycin could kill Enterococcus in vitro and that the administered dose was significantly lower after the combination treatment, which could reduce adverse effects and the development of drug resistance. The potential mechanism of the two-drug combination against Enterococcus was revealed from a quantitative perspective, which is an important step toward dose optimization in simulated humans.

Funder

Anhui Medical University

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00871-21

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