Chemotherapeutic Potential of Orally Administered Poly(Lactide-Co-Glycolide) Microparticles Containing Isoniazid, Rifampin, and Pyrazinamide against Experimental Tuberculosis-Reference-Cited by-同舟云学术

Chemotherapeutic Potential of Orally Administered Poly(Lactide-Co-Glycolide) Microparticles Containing Isoniazid, Rifampin, and Pyrazinamide against Experimental Tuberculosis

Published:2003-09 Issue:9 Volume:47 Page:3005-3007
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

ul-Ain Qurrat¹,Sharma Sadhna¹,Khuller G. K.¹

Affiliation:

1. Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India

Abstract

ABSTRACT Poly(lactide-co-glycolide) (PLG) microspheres (diameter, less than 3 μm) containing isoniazid, rifampin, and pyrazinamide were used in a sustained oral drug delivery system to treat murine tuberculosis. Drug levels above the MIC were observed up to 72 h in plasma and for 9 days in various organs. Relative bioavailability of encapsulated drugs was greater than that of free drugs. Chemotherapy results showed better or equivalent clearance of bacilli in the PLG-drug-administered group (weekly) than with free drugs (daily).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.9.3005-3007.2003

Reference10 articles.

1. Arangoa, M. A., M. A. Camanero, M. J. Renedo, G. Ponchel, and J. M. Irache. 2001. Gliadin nanoparticles as carriers for the oral administration of lipophilic drugs: relationship between bioadhesion and pharmacokinetics. Pharm. Res.18:1521-1527.

2. Dutt, M., and G. K. Khuller. 2001. Chemotherapy of Mycobacterium tuberculosis infections in mice by combination of isoniazid and rifampicin drugs entrapped in poly (DL-lactide-co-glycolide) microparticles. J. Antimicrob. Chemother.47:829-835.

3. Dutt, M., and G. K. Khuller. 2001. Sustained release of isoniazid from single injectable dose of poly (DL-lactide-co-glycolide) microparticles as a therapeutic approach towards tuberculosis. Int. J. Antimicrob. Agents17:115-122.

4. Therapeutic Efficacy of Poly( dl -Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against Mycobacterium tuberculosis Infection Induced in Mice

5. Edwards, D. A., J. Hanes, G. Caponetti, J. Hrkach, A. B. Jebria, M. L. Eskew, J. Mintzes, D. Deaver, N. Lotan, and R. Langer. 1997. Large porous particles for pulmonary drug delivery. Science275:1868-1871.

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