The Biosynthetic Pathway of Ubiquinone Contributes to Pathogenicity of Francisella novicida-Reference-Cited by-同舟云学术

The Biosynthetic Pathway of Ubiquinone Contributes to Pathogenicity of Francisella novicida

Published:2021-11-05 Issue:23 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Kazemzadeh Katayoun¹,Hajj Chehade Mahmoud¹,Hourdoir Gautier¹,Brunet Camille Dorothée¹,Caspar Yvan²³,Loiseau Laurent⁴,Barras Frederic⁵⁶^ORCID,Pierrel Fabien¹^ORCID,Pelosi Ludovic¹^ORCID

Affiliation:

1. CNRS, CHU Grenoble Alpes, Grenoble INP, TIMC, Université Grenoble Alpes, Grenoble, France

2. Laboratoire de Bactériologie-Hygiène Hospitalière, Centre National de Référence des Francisella, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France

3. Université Grenoble Alpes, CHU Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France

4. Aix Marseille Université, CNRS, Laboratoire Chimie Bactérienne, Institut Microbiologie de la Méditerranée, Marseille, France

5. SAMe Unit, Department of Microbiology, Institut Pasteur, Paris, France

6. IMM-UMR 2001 CNRS-Institut Pasteur, Paris, France

Abstract

Francisella tularensis is the causative bacterium of tularemia and is classified as a biothreat agent. Using multidisciplinary approaches, we investigated the ubiquinone (UQ) biosynthetic pathway that operates in F. novicida used as a surrogate.

Funder

Agence Nationale de la Recherche

Université Grenoble Alpes

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00400-21

Reference47 articles.

1. Special Topic on Francisella tularensis and Tularemia

2. Francisella Inflammasomes: Integrated Responses to a Cytosolic Stealth Bacterium