Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Author:

Collado M. Carmen1,Derrien Muriel2,Isolauri Erika3,de Vos Willem M.24,Salminen Seppo1

Affiliation:

1. Functional Foods Forum, University of Turku, FI-20014 Turku, Finland

2. Laboratory of Microbiology, Wageningen University, 6703 HB Wageningen, The Netherlands

3. Department of Pediatrics, University of Turku, FI-20014 Turku, Finland

4. Department of Basic Veterinary Sciences, Helsinki University, FI-00014 Helsinki, Finland

Abstract

ABSTRACT Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila -like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10 8 cells/g) but decreases ( P < 0.05) in the elderly.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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