In VitroSusceptibility ofMadurella mycetomatisto Posaconazole and Terbinafine

Abstract

ABSTRACTPresently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, thein vitrosusceptibilities of 34Madurella mycetomatisstrains were determined. It appeared that posaconazole was highly active againstM. mycetomatisbut terbinafine was only moderately active. Since posaconazole has an excellent safety profile, it might provide an important alternative in mycetoma therapy.