Spread of Plasmids Carrying Multiple GES Variants-Reference-Cited by-同舟云学术

Spread of Plasmids Carrying Multiple GES Variants

Published:2016-08 Issue:8 Volume:60 Page:5040-5043
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cuzon Gaelle¹²³,Bogaerts Pierre⁴,Bauraing Caroline⁴,Huang Te-Din⁴,Bonnin Rémy A.¹²³⁵^ORCID,Glupczynski Youri⁴,Naas Thierry¹²³⁵

Affiliation:

1. Bactériologie-Hygiene Unit, APHP, Bicêtre Hospital, Le Kremlin-Bicêtre, France

2. Université Paris Sud, Université Paris Saclay, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bicetre, France

3. French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France

4. Belgian National Reference Centre for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant-Godinne UCL Namur, Université Catholique de Louvain, Yvoir, Belgium

5. Evolution and Ecology of Resistance to Antibiotics (EERA) Unit, Institut Pasteur-APHP-Université Paris Sud, Le Kremlin-Bicetre, France

Abstract

ABSTRACT Five GES-producing Enterobacteriaceae isolates that displayed an extended-spectrum β-lactamase (ESBL) phenotype harbored two GES variants: GES-7 ESBL and GES-6 carbapenemase. In all isolates, the two GES alleles were located on the same integron that was inserted into an 80-kb IncM1 self-conjugative plasmid. Whole-genome sequencing suggested in vivo horizontal gene transfer of the plasmid along with clonal diffusion of Enterobacter cloacae . To our knowledge, this is the first description in Europe of clustered Enterobacteriaceae isolates carrying two GES β-lactamases, of which one has extended activity toward carbapenems.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00360-16

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