Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase

Author:

Stewart Nichole K.1,Toth Marta1,Quan Pojun2,Beer Michael34ORCID,Buynak John D.2ORCID,Smith Clyde A.56ORCID,Vakulenko Sergei B.1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States

2. Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States

3. School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, U.K.

4. Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.

5. Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California 94025, United States

6. Department of Chemistry, Stanford University, Stanford, California 94305, United States

Funder

Basic Energy Sciences

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

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