Host Genetic Resistance to Symptomatic Norovirus (GGII.4) Infections in Denmark-Reference-Cited by-同舟云学术

Host Genetic Resistance to Symptomatic Norovirus (GGII.4) Infections in Denmark

Published:2007-08 Issue:8 Volume:45 Page:2720-2722
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Kindberg Elin¹²,Åkerlind Britt³,Johnsen Christina⁴,Knudsen Jenny Dahl⁵,Heltberg Ole⁶,Larson Göran⁷,Böttiger Blenda⁴,Svensson Lennart¹

Affiliation:

1. Division of Molecular Virology, Medical Faculty, University of Linköping, Linköping, Sweden

2. Department of Forensic Genetics, National Board of Forensic Medicine, Linköping, Sweden

3. Division of Clinical Microbiology, University Hospital, Linköping, Sweden

4. Department of Virology, Statens Serum Institut, Copenhagen, Denmark

5. Department of Microbiology, Hvidovre Hospital, Hvidovre, Denmark

6. Department of Microbiology, Næstved Hospital, Næstved, Denmark

7. Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg, Sweden

Abstract

ABSTRACT A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation ( P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00162-07

Reference19 articles.

1. Norwalk virus antigen and antibody response in an adult volunteer study

2. Henry, S., R. Mollicone, J. B. Lowe, B. Samuelsson, and G. Larson. 1996. A second nonsecretor allele of the blood group alpha(1,2)fucosyl-transferase gene (FUT2). Vox Sang.70:21-25.

3. Hutson, A. M., F. Airaud, J. LePendu, M. K. Estes, and R. L. Atmar. 2005. Norwalk virus infection associates with secretor status genotyped from sera. J. Med. Virol.77:116-120.

4. Food-Borne Outbreak of Gastroenteritis Associated with Genogroup I Calicivirus

5. Kelly, R. J., S. Rouquier, D. Giorgi, G. G. Lennon, and J. B. Lowe. 1995. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2): homozygosity for an enzyme- inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J. Biol. Chem.270:4640-4649.

Cited by 67 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Formation of Genetically Determined Resistance against Human Norovirus Infection through Polymorphism of the FUT2 gene: a Review of the Literature;Epidemiology and Vaccinal Prevention;2024-01-06

2. Key risk factors of asthma-like symptoms are mediated through infection burden in early childhood;Journal of Allergy and Clinical Immunology;2023-11

3. Genetic Associations with Coronavirus Susceptibility and Disease Severity;Advances in Experimental Medicine and Biology;2023

4. Risk Assessment of Norovirus Illness from Consumption of Raw Oysters in the United States and in Canada;Risk Analysis;2021-06-13

5. Targeted Profiling of Immunological Genes during Norovirus Replication in Human Intestinal Enteroids;Viruses;2021-01-21