Affiliation:
1. Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294
Abstract
ABSTRACT
Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II
Streptococcus mutans
. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven specific open reading frames: a regulator (
mutR
), the prepromutacin structural gene (
mutA
), a modifying protein (
mutM
), an ABC transporter (
mutT
), and an immunity cluster (
mutFEG
). Transformations of a non-mutacin-producing strain,
S. mutans
UA159, and a mutacin I-producing strain,
S. mutans
UA140, with chromosomal DNA from
S. mutans
T8 with an
aphIII
marker inserted upstream of the mutacin II structural gene yielded transformants producing mutacin II and mutacins I and II, respectively.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Cited by
51 articles.
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