Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound-Reference-Cited by-同舟云学术

Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rued Britta E.¹^ORCID,Covington Brett C.²,Bushin Leah B.²,Szewczyk Gabriella¹,Laczkovich Irina¹,Seyedsayamdost Mohammad R.²,Federle Michael J.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA

2. Department of Chemistry, Princeton University, Princeton, New Jersey, USA

Abstract

Bacteria interact and compete with a large community of organisms in their natural environment. Streptococcus mutans is one such organism, and it is an important member of the oral microbiota. We found that S. mutans uses a quorum-sensing system to regulate production of a novel posttranslationally modified peptide capable of inhibiting growth of several streptococcal species.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Burroughs Wellcome Fund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02688-20

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