N -Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase-Reference-Cited by-同舟云学术

N -Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase

Published:2002-08 Issue:8 Volume:46 Page:2450-2457
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Siemann Stefan¹,Evanoff Darryl P.¹,Marrone Laura¹,Clarke Anthony J.²,Viswanatha Thammaiah¹,Dmitrienko Gary I.¹

Affiliation:

1. Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1

2. Canadian Bacterial Diseases Network, Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada

Abstract

ABSTRACT Members of a family of N -arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-β-lactamase activity exhibited by this class of compounds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.8.2450-2457.2002

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