Peptidoglycan Recycling Promotes Outer Membrane Integrity and Carbapenem Tolerance in Acinetobacter baumannii-Reference-Cited by-同舟云学术

Peptidoglycan Recycling Promotes Outer Membrane Integrity and Carbapenem Tolerance in Acinetobacter baumannii

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Islam Nowrosh¹,Kazi Misha I.¹,Kang Katie N.¹,Biboy Jacob²,Gray Joe³,Ahmed Feroz¹,Schargel Richard D.¹,Boutte Cara C.¹^ORCID,Dörr Tobias⁴⁵⁶,Vollmer Waldemar²,Boll Joseph M.¹^ORCID

Affiliation:

1. Department of Biology, University of Texas—Arlington, Arlington, Texas, USA

2. Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

3. Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

4. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA

5. Department of Microbiology, Cornell University, Ithaca, New York, USA

6. Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, New York, USA

Abstract

Carbapenem treatment failure associated with “superbug” infections has rapidly increased in prevalence, highlighting the urgent need to develop new therapeutic strategies. Antibiotic tolerance can directly lead to treatment failure but has also been shown to promote the acquisition of true resistance within a population.

Funder

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Research Councils UK

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01001-22

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1. The outer membrane is an essential load-bearing element in Gram-negative bacteria