More Is Not Always Better—the Double-Headed Role of Fibronectin in Staphylococcus aureus Host Cell Invasion

Author:

Niemann Silke1ORCID,Nguyen Minh-Thu1ORCID,Eble Johannes A.2ORCID,Chasan Achmet I.3ORCID,Mrakovcic Maria14,Böttcher Ralph T.5,Preissner Klaus T.6,Roßlenbroich Steffen7,Peters Georg1,Herrmann Mathias1

Affiliation:

1. Institute of Medical Microbiology, University Hospital Münster, Münster, Germany

2. Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany

3. Institute of Immunology, University of Münster, Münster, Germany

4. Institute of Infectiology, University of Münster, Münster, Germany

5. Department of Molecular Medicine, Max Planck Institute for Biochemistry, Martinsried, Germany

6. Kerckhoff-Herzforschungsinstitut, Department of Cardiology, Medical School, Justus-Liebig-University, Giessen, Germany

7. Department of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany

Abstract

Traditionally, Staphylococcus aureus has been considered an extracellular pathogen. However, among other factors, the frequent failure of antimicrobial therapy and the ability of the pathogen to cause recurrent disease have established the concept of eukaryotic invasion of the pathogen, thereby evading the host’s immune system.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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