Interactions between Viral Regulatory Proteins Ensure an MOI-Independent Probability of Lysogeny during Infection by Bacteriophage P1-Reference-Cited by-同舟云学术

Interactions between Viral Regulatory Proteins Ensure an MOI-Independent Probability of Lysogeny during Infection by Bacteriophage P1

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhang Kailun¹²,Pankratz Kiara¹,Duong Hau¹,Theodore Matthew¹²,Guan Jingwen¹²³,Jiang Anxiao (Andrew)⁴,Lin Yiruo⁴,Zeng Lanying¹²³^ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA

2. Center for Phage Technology, Texas A&M University, College Station, Texas, USA

3. Molecular and Environmental Plant Sciences, Texas A&M University, College Station, Texas, USA

4. Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA

Abstract

Phage P1 has been shown potentially to play an important role in disseminating antibiotic resistance among bacteria during lysogenization, as evidenced by the prevalence of P1 phage-like elements in animal and human pathogens. In contrast to phage λ, a cell fate decision-making paradigm, P1 lysogenization was shown to be independent of MOI.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01013-21

Reference77 articles.

1. Bacteriophages as Vehicles for Antibiotic Resistance Genes in the Environment

2. Characterization of a P1-Like Bacteriophage Carrying an SHV-2 Extended-Spectrum β-Lactamase from an Escherichia coli Strain