Comparison of Cefoxitin and Cephalothin Therapy of a Mixed Bacteroides fragilis and Fusobacterium necrophorum Infection in Mice

Author:

Hackman A. S.1,Wilkins T. D.1

Affiliation:

1. Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061

Abstract

Cefoxitin, a β-lactamase-resistant cephalosporin, was found to be more effective than cephalothin against an experimental mixed infection containing Bacteroides fragilis and Fusobacterium necrophorum .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference5 articles.

1. The determination of the dosage-mortality curve from small numbers;Bliss C. I.;Q. J. Pharm. Pharmacol.,1938

2. In vivo protection of Fusobacterium necrophorum from penicillin by Bacteroides fragilis;Hackman A. S.;Antimicrob. Agents Chemother.,1975

3. Holdeman L. V. and W. E. C. Moore (ed). 1972. Anaerobe laboratory manual. Virginia Polytechnic Institute and State University Blacksburg Va

4. Cefoxitin, a semisynthetic cephamycin antibiotic: susceptibility studies;Wallick H.;Antimicrob. Agents Chemother.,1974

5. Chemotherapy of an experimental Fusobacterium (Sphaerophorus) necrophorum infection in mice;Wilkins T. D.;Antimicrob. Agents Chemother.,1974

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