Affiliation:
1. Anaerobe Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060
Abstract
An experimental animal model for testing antibiotics in vivo against
Fusobacterium
(
Sphaerophorus
)
necrophorum
has been developed. It incorporates the subcutaneous injection of the bacteria into mice followed by intraperitoneal administration of the antibiotic at 24, 48, 72, and 96 h. Mean effective dose values are based on the number of survivors 21 days after challenge. Tetracycline was the most effective drug tested, with a mean effective dose of 5.0 mg/kg, compared with mean effective dose values of 11.1 for clindamycin, 11.8 for penicillin-G, and 52.9 for lincomycin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference16 articles.
1. Treatment of anaerobic infections with lincomycin and clindamycin;Bartlett J. G.;New Engl. J. Med.,1972
2. The determination of the dosage-mortality curve from small numbers;Bliss C. I.;Quart. J. Pharm. Pharmacol.,1938
3. Isolation of L-type cultures from Bacteroides with the aid of penicillin and their reversion into the usual bacilli;Dienes L.;J. Bacteriol.,1948
4. Clindamycin in the treatment of serious anaerobic infections;Fass R. J.;Ann. Intern. Med.,1973
5. Bacteroides;Felner J. M.;bacteremia. Amer. J. Med.,1971
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献