Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence of De Novo Phosphatidylethanolamine Synthesis-Reference-Cited by-同舟云学术

Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence of De Novo Phosphatidylethanolamine Synthesis

Published:2018-08 Issue:8 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Davis Sarah E.¹,Tams Robert N.¹,Solis Norma V.²,Wagner Andrew S.¹,Chen Tian¹,Jackson Joseph W.¹,Hasim Sahar¹,Montedonico Anthony E.¹,Dinsmore Justin¹,Sparer Timothy E.¹,Filler Scott G.²,Reynolds Todd B.¹

Affiliation:

1. Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA

2. Department of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA

Abstract

Candida albicans mutants for phosphatidylserine (PS) synthase ( cho1 ΔΔ) and PS decarboxylase ( psd1 ΔΔ psd2 ΔΔ) are compromised for virulence in mouse models of systemic infection and oropharyngeal candidiasis (OPC). Both of these enzymes are necessary to synthesize phosphatidylethanolamine (PE) by the de novo pathway, but these mutants are still capable of growth in culture media, as they can import ethanolamine from media to synthesize PE through the Kennedy pathway.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00815-17

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