Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome

Author:

Martins Mauricio A.1ORCID,Gonzalez-Nieto Lucas1,Ricciardi Michael J.1,Bailey Varian K.1,Dang Christine M.1,Bischof Georg F.1,Pedreño-Lopez Nuria1,Pauthner Matthias G.2,Burton Dennis R.2,Parks Christopher L.3,Earl Patricia4,Moss Bernard4ORCID,Rakasz Eva G.5,Lifson Jeffrey D.6,Desrosiers Ronald C.1ORCID,Watkins David I.1

Affiliation:

1. Department of Pathology, University of Miami, Miami, Florida, USA

2. Department of Immunology and Microbiology, IAVI Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, USA

3. International AIDS Vaccine Initiative, AIDS Vaccine Design and Development Laboratory, Brooklyn, New York, USA

4. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

5. Wisconsin National Primate Research Center, University of Wisconsin–Madison, Madison, Wisconsin, USA

6. AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

Abstract

Our results are relevant to HIV vaccine development efforts because they suggest that increasing the number of booster immunizations or delivering additional viral antigens may not necessarily improve vaccine efficacy against immunodeficiency virus infection.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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