Temperature Effect on the Susceptibility of Methicillin-Resistant Staphylococcus aureus to Four Different Cephalosporins

Author:

Canawati Hanna N.12,Witte Joyce L.3,Sapico Francisco L.13

Affiliation:

1. University of Southern California School of Medicine, Los Angeles, California 90033,

2. Department of Pathology Rancho Los Amigos Hospital, Downey, California 90242

3. Department of Medicine,* Rancho Los Amigos Hospital, Downey, California 90242

Abstract

Forty isolates of methicillin-resistant Staphylococcus aureus were tested for in vitro susceptibility to cephalothin, cefamandole, cefotaxime, and moxalactam, using the disk diffusion and microbroth dilution methods at incubation temperatures of 30 and 35°C. Resistance to all four antibiotics was more clearly evident at an incubation temperature of 30°C.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference17 articles.

1. Acar J. F. P. Courvalin and Y. A. Chabbert. 1971. Methicillin-resistant staphylococcemia: bacteriological failure of treatment with cephalosporins p. 280-285. Antimicrob. Agents Chemother. 1970.

2. The effect of temperature on resistance of Staphylococcus aureus to methicillin and some other antibiotics;Annear D. I.;Med. J. Aust.,1968

3. An improved single-disk method for testing the anaerobic susceptibility of rapidly growing pathogens;Barry A. L.;Am. J. Clin. Pathol.,1970

4. Antibiotic susceptibility testing by a standardized disk method;Bauer A. W.;Am. J. Clin. Pathol.,1966

5. Epidemiologic studies of an outbreak of nosocomial methicillin-resistant Staphylococcus aureus infections;Boyce J. M.;Infect. Control,1981

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