The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes-Reference-Cited by-同舟云学术

The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hörömpöli Daniel¹²^ORCID,Ciglia Catherine³,Glüsenkamp Karl-Heinz⁴,Haustedt Lars Ole⁵,Falkenstein-Paul Hildegard⁶,Bendas Gerd⁶,Berscheid Anne¹²³^ORCID,Brötz-Oesterhelt Heike¹²³⁷^ORCID

Affiliation:

1. Interfaculty Institute of Microbiology and Infection Medicine, Department of Microbial Bioactive Compounds, University of Tuebingen, Tuebingen, Germany

2. German Center of Infection Research (DZIF), Partner Site Tuebingen, Tuebingen, Germany

3. Institute of Pharmaceutical Biology, University of Duesseldorf, Duesseldorf, Germany

4. Squarix GmbH, Marl, Germany

5. AnalytiCon Discovery GmbH, Potsdam, Germany

6. Pharmaceutical Institute, Department of Pharmaceutical & Cell Biological Chemistry, University of Bonn, Bonn, Germany

7. Cluster of Excellence 2124: Controlling Microbes to Fight Infection, Tuebingen, Germany

Abstract

Negamycin is a natural pseudodipeptide antibiotic with promising activity against Gram-negative and Gram-positive bacteria, including Enterobacteriaceae , Pseudomonas aeruginosa , and Staphylococcus aureus , and good efficacy in infection models. It binds to ribosomes with a novel binding mode, stimulating miscoding and inhibiting ribosome translocation.

Funder

Deutsches Zentrum für Infektionsforschung

Bundesministerium für Bildung und Forschung

Studienstiftung des Deutschen Volkes

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00986-20

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