Meiosis-Specific Functions of Kinesin Motors in Cohesin Removal and Maintenance of Chromosome Integrity in Budding Yeast-Reference-Cited by-同舟云学术

Meiosis-Specific Functions of Kinesin Motors in Cohesin Removal and Maintenance of Chromosome Integrity in Budding Yeast

Published:2020-03-30 Issue:8 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Mittal Priyanka¹,Ghule Komal²,Trakroo Deepika²,Prajapati Hemant Kumar¹,Ghosh Santanu K.²

Affiliation:

1. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

2. Department of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, Powai, Mumbai, India

Abstract

Kinesin motors provide the molecular forces at the kinetochore-microtubule interface and along the spindle to control chromosome segregation. During meiosis with two rounds of microtubule assembly-disassembly, the roles of motor proteins remain unexplored. We observed that in contrast to mitosis, Cin8 and Kip3 together are indispensable for meiosis. While examining meiosis in cin8 Δ kip3 Δ cells, we detected chromosome breakage in the meiosis II cells.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

University Grants Commission

Council of Scientific and Industrial Research, India

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00386-19

Reference104 articles.

1. Division of the Nucleolus and Its Release of CDC14 during Anaphase of Meiosis I Depends on Separase, SPO12, and SLK19