Author:
Golparian Daniel,Shafer William M.,Ohnishi Makoto,Unemo Magnus
Abstract
ABSTRACTThe contribution of drug efflux pumps in clinical isolates ofNeisseria gonorrhoeaethat express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
89 articles.
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