Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages-Reference-Cited by-同舟云学术

Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages

Published:2004-06 Issue:6 Volume:48 Page:2325-2330
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ewart Gary D.¹,Nasr Najla²,Naif Hassan²,Cox Graeme B.³,Cunningham Anthony L.²,Gage Peter W.³

Affiliation:

1. Biotron Limited

2. Westmead Millenium Institute, Westmead, NSW 2145, Australia

3. John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601

Abstract

ABSTRACT We report that the amiloride analogues 5-( N , N -hexamethylene)amiloride and 5-( N , N -dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.6.2325-2330.2004

Reference17 articles.

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2. Carr, J. M., H. Hocking, P. Li, and C. J. Burrell. 1999. Rapid and efficient cell to cell transmission of human immunodeficiency virus infection from monocyte-derived macrophages to peripheral blood lymphocytes. Virology265:319-329.

3. Du, B., A. Wolf, S. Lee, and E. Terwilliger. 1993. Changes in the host range and growth potential of an HIV-1 clone are conferred by the vpu gene. Virology195:260-264.

4. Ewart, G. D., K. Mills, G. B. Cox, and P. W. Gage. 2002. Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu. Eur. Biophys. J.31:26-35.

5. The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels

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