Limited Polymorphism in the Dihydropteroate Synthetase Gene ( dhps ) of Plasmodium vivax Isolates from Thailand-Reference-Cited by-同舟云学术

Limited Polymorphism in the Dihydropteroate Synthetase Gene ( dhps ) of Plasmodium vivax Isolates from Thailand

Published:2005-10 Issue:10 Volume:49 Page:4393-4395
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Imwong Mallika¹,Pukrittayakamee Sasithon¹,Cheng Qin²,Moore Catrin³,Looareesuwan Sornchai¹,Snounou Georges⁴,White Nicholas J.¹³,Day Nicholas P. J.¹³

Affiliation:

1. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Drug Resistance and Diagnostics Department, Australian Army Malaria Institute, Brisbane, Queensland, Australia

3. Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom

4. Unité de Parasitologie Biomédicale, CNRS URA 2581, Institut Pasteur, Paris, France

Abstract

ABSTRACT The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pv dhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of Pv dhps and Pv dhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.10.4393-4395.2005

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