Characterization of the Naturally Occurring Oxacillinase of Acinetobacter baumannii-Reference-Cited by-同舟云学术

Characterization of the Naturally Occurring Oxacillinase of Acinetobacter baumannii

Published:2005-10 Issue:10 Volume:49 Page:4174-4179
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Héritier Claire¹,Poirel Laurent¹,Fournier Pierre-Edouard²³,Claverie Jean-Michel³,Raoult Didier²,Nordmann Patrice¹

Affiliation:

1. Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 K.-Bicêtre

2. Unité des Rickettsies, IFR 48, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée

3. IGS, CNRS UPR2589, Marseille, France

Abstract

ABSTRACT A chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. β-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla OXA-69 -like genes were identified in all A. baumannii strains tested ( n = 12), suggesting that this oxacillinase is naturally occurring in that species.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.10.4174-4179.2005

Reference36 articles.

1. Characterization of OXA-25, OXA-26, and OXA-27, Molecular Class D β-Lactamases Associated with Carbapenem Resistance in Clinical Isolates of Acinetobacter baumannii

2. Expression of the AsbA1, OXA-12, and AsbM1 beta-lactamases in Aeromonas jandaei AER 14 is coordinated by a two-component regulon

3. Barbe, V., D. Vallenet, N. Fonknechten, A. Kreimeyer, S. Oztas, L. Labarre, S. Cruveiller, C. Robert, S. Duprat, P. Wincker, L. N. Ornston, J. Weissenbach, P. Marliere, G. N. Cohen, and C. Medigue. 2004. Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium. Nucleic Acids Res.32:5766-5779.

4. Bergogne-Bérézin, E., M. L. Joly-Guillou, and K. J. Towner. 1996. Epidemiology of Acinetobacter spp. p. 71-100. In K. J. Towner et al. (ed.), Acinetobacter: microbiology, epidemiology, infections, management. CRC Press, Inc., Boca Raton, Fla.

5. OXA-24, a Novel Class D β-Lactamase with Carbapenemase Activity in an Acinetobacter baumannii Clinical Strain

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