The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide-Reference-Cited by-同舟云学术

The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide

Published:2019-09-15 Issue:18 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Oleson Bryndon J.¹,Broniowska Katarzyna A.¹,Yeo Chay Teng¹,Flancher Michael¹,Naatz Aaron¹,Hogg Neil²,Tarakanova Vera L.³,Corbett John A.¹

Affiliation:

1. Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

2. Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

3. Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

Abstract

In this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832/13 and rat islets by inhibiting intermediary metabolism. Nitric oxide is known to inhibit complex IV of the electron transport chain and aconitase of the Krebs cycle.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

American Heart Association

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00153-19

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