African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING-Reference-Cited by-同舟云学术

African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING

Published:2023-09-28 Issue:9 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ye Guangqiang¹,Liu Hongyang¹,Liu Xiaohong¹,Chen Weiye¹,Li Jiangnan¹²,Zhao Dongming¹^ORCID,Wang Gang³,Feng Chunying¹,Zhang Zhaoxia¹²,Zhou Qiongqiong¹,Zheng Jun¹²,Bu Zhigao¹^ORCID,Weng Changjiang¹²^ORCID,Huang Li¹²^ORCID

Affiliation:

1. Division of Fundamental Immunology, National African Swine Fever Para-reference Laboratory, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

2. Heilongjiang Provincial Key Laboratory of Veterinary Immunology, Harbin, China

3. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian, China

Abstract

African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and acute hemorrhagic viral disease with a high mortality, approaching 100% in domestic pigs. However, the relationship between viral pathogenicity and immune evasion of ASFV is not fully understood, which limits the development of safe and effective ASF vaccines, specifically, live attenuated vaccines.

Funder

Natural Science Foundation of Heilongjiang Province

MOST | National Key Research and Development Program of China

MOST | National Natural Science Foundation of China

CAAS | HVRI, CAAS | State Key Laboratory of Veterinary Biotechnology

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00577-23

Reference32 articles.