Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA-Reference-Cited by-同舟云学术

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Published:2021-08-25 Issue:18 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Liu Fei¹^ORCID,Lee Amy C. H.¹,Guo Fang¹,Kondratowicz Andrew S.¹,Micolochick Steuer Holly M.¹,Miller Angela¹,Bailey Lauren D.¹,Wang Xiaohe¹,Chen Shuai¹,Kultgen Steven G.¹,Cuconati Andrea¹,Cole Andrew G.¹,Gotchev Dimitar¹,Dorsey Bruce D.¹,Rijnbrand Rene¹,Lam Angela M.¹,Sofia Michael J.¹,Gao Min¹

Affiliation:

1. Arbutus Biopharma, Warminster, Pennsylvania, USA

Abstract

Chronic hepatitis B affects more than 250 million patients and is a major public health concern worldwide. HBsAg plays a central role in maintaining HBV persistence, and as such, therapies that aim at reducing HBsAg through destabilizing or degrading HBV RNA have been extensively investigated.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00574-21

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