Structure–Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer-Reference-Cited by-同舟云学术

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Structure–Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer

Published:2024-01-08 Issue:2 Volume:67 Page:1421-1446
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gotchev Dimitar¹^ORCID,Dorsey Bruce D.¹,Nguyen Duyan¹,Kakarla Ramesh¹,Dugan Benjamin¹,Chen Shuai¹,Gao Min¹,Bailey Laurèn¹^ORCID,Liu Fei¹,Harasym Troy¹,Chiu Tim¹,Tang Sunny¹,Lee Amy C.-H.¹^ORCID,Cole Andrew G.¹,Sofia Michael J.¹

Affiliation:

1. Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01981

Reference31 articles.

1. Hepatitis B; World Health Organization (WHO), 2023; https://www.who.int/news-room/fact-sheets/detail/hepatitis-b (accessed 2023-07-24).

2. Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus

3. Impaired function of hepatic natural killer cells from murine chronic HBsAg carriers

4. Hepatitis B virus surface antigen suppresses the activation of monocytes through interaction with a serum protein and a monocyte-specific receptor

5. Immune and Viral Profile from Tolerance to Hepatitis B Surface Antigen Clearance: a Longitudinal Study of Vertically Hepatitis B Virus-Infected Children on Combined Therapy

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