The Porphyromonas gingivalis Hybrid Cluster Protein Hcp Is Required for Growth with Nitrite and Survival with Host Cells-Reference-Cited by-同舟云学术

The Porphyromonas gingivalis Hybrid Cluster Protein Hcp Is Required for Growth with Nitrite and Survival with Host Cells

Published:2019-04 Issue:4 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Belvin B. Ross¹²^ORCID,Gui Qin¹,Hutcherson Justin A.¹,Lewis Janina P.¹³²

Affiliation:

1. Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, USA

2. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA

3. Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA

Abstract

Although the periodontal pathogen Porphyromonas gingivalis must withstand high levels of nitrosative stress while in the oral cavity, the mechanisms of nitrosative stress defense are not well understood in this organism. Previously we showed that the transcriptional regulator HcpR plays a significant role in defense, and here we further defined its regulon.

Funder

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00572-18

Reference49 articles.

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2. Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview

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