The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes

Author:

Saila Susan1,Gyanwali Gaurav Chandra1,Hussain Mazhar1,Gianfelice Antonella1,Ireton Keith1

Affiliation:

1. Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand

Abstract

Listeria monocytogenes is a foodborne bacterium that causes gastroenteritis, meningitis, or abortion. Listeria induces its internalization (entry) into some human cells through interaction of the bacterial surface protein InlB with its host receptor, the Met tyrosine kinase. InlB and Met promote entry through stimulation of localized actin polymerization and exocytosis. How actin cytoskeletal changes and exocytosis are controlled during entry is not well understood.

Funder

University of Otago Research Committee

Manatu Hauora | Health Research Council of New Zealand

Marsden Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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